The draw for the semi-final of the Carabao Cup was conducted on Wednesday night.
Southampton, who eliminated Premier League champions Manchester City, will take on Newcastle United.
Manchester United, the hot favourites to win the competition face Nottingham Forest.
The two-legged ties will take place in the week commencing January 23 and January 30 respectively.
The final will be played February 26 at Wimbledon.
Carabao Cup semi-final draw:
Southampton v Newcastle United
Nottingham Forest v Manchester Utd